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Duration: 30 month, 1st January 2000 - 30th June 2002, Funding: approx. 2.100.000 (EC Contribution), Resources: approx. 750 person month
Information Society Technologies Programme (IST) is a single, integrated research program that builds on the convergence of information processing, communications and media technologies. IST has an indicative budget of 3.600 Million Euro, and is managed by the Information Society DG of the European Commission.
The project will develop minimally invasive therapy for tumors guided by VR images and ultrasound. It will create an integrated brachytherapy system, using online 3D ultrasound images for guidance and navigation systems for seeds or catheters in the context of organ infusion of drugs, chemotherapy etc. Dutch partner in the project is Nucletron bv.
Present treatment conditions have a number of shortcomings. Prior to insertion of catheters, usually a CT scan or X-Ray film (occasionally a 2D-U/S scan is used for prostate) is conducted as basis for planning the number and position of radioactive sources necessary. After insertion of the catheters, an additional scan is required to reconstruct their final positions. Present planning systems are capable of calculating the radiation pattern as the result of this geometry. Such systems are however incapable of solving the inverse problem, i.e. calculating the optimum position of needles once the required or desired amount of radiation on the target volume has been defined. Furthermore, the static CT picture is a poor basis for conducting the radiation itself for two reasons: First, the position of the patient can be different between CT acquisition and treatment, especially when soft tissue is involved. Second, CT scan acquired prior to the needle insertion provides no real-time indication of true position after insertion in the body relative to their planned position. Third, a CT scan is often not available in the radio-oncology department.
The software toolkit WinOpt-HDR together with the 3D ultrasound acquisition and volume rendering software InViVo-ScanNT from the Fraunhofer Institute for Computer Graphics and MedCom Gesellschaft für medizinische Bildverarbeitung mbH are extended and used to create a dual usage brachytherapy system employing catheters (HDR) using 3D-ultrasound images rather than CT scans. The system includes the following main components:
Patient
modelling system based mainly on 3D-ultrasound either than on CT
scans. 3D-U/S is much cheaper, widely available and an uncomplicated
procedure as compared with CT
Inverse
planing system using the segmented anatomy as stated above derived
from 3D-U/S, CT, or from a combination of the two (fusion),
calculating the minimum number and the optimal position of catheters
to deliver the desired dose on the specified area. An innovative
method and an anatomy based 3D-dosage optimisation will solve the
inverse problem starting from the desired irradiation pattern and
delivering number and location of implants
Navigation
system based on templates or magnetic tracker information which will
give doctors for the first time the possibility of seeing the result
of their action in real time and will enable them to position
implants accurately in the positions defined by the pre-planing. This
will increase the effectiveness of the treatment and enable accurate
records to be kept
Anatomy
Based Optimisation based on genetic algorithms and fine-tuning the
dose delivery to compensate differences between ideal and real
implant position
Telemedical features allowing the on-line communication of experts. Unlike previous "teleradiology-motivated" approaches, our approach will enable co-operation during the planing phase as well during the interventional application of treatment
Personal References for the MITTUG project
M. Lahanas, D. Baltas and N. Zamboglou, Anatomy-based three-dimensional dose optimization in brachytherapy using multiobjective genetic algorithms, Med. Phys. 26 1904-1918, 1999
M. Lahanas, D. Baltas, N. Milickovic, S. Giannouli and N. Zamboglou, Generation of uniformly distributed dose points for anatomy-based-three-dimensional dose optimization in brachytherapy, Med. Phys. 27 1034-1046, 2000
N. Milickovic, S. Giannouli, D. Baltas, M. Lahanas, N. Zamboglou and N. Uzunoglou. Catheter autoreconstruction in CT based brachytherapy treatment planning, Med. Phys. 26 1047-1057, 2000
Abstract
N. Milickovic, S. Giannouli, D. Baltas, M. Lahanas, N. Zamboglou and N. Uzunoglou. Algorithm for autoreconstruction of catheters in computer tomography-based brachytherapy treatment planning, IEEE, Transactions on Biomedical Engineering, 48 No. 3, 372-383, 2001
S. Giannouli, D. Baltas, N. Milickovic, M. Lahanas, C. Kolotas, N. Zamboglou and N. Uzunoglu. Autoactivation of Source Dwell Positions for HDR Brachytherapy Treatment Planning, Med. Phys. 27 2517-2520, 2000
T. Kemmerer, M. Lahanas, D. Baltas and N. Zamboglou, DVH computation comparisons using conventional methods and optimized FFT algorithms for brachytherapy, Med. Phys. 27 2343-2356, 2000
M. Lahanas, T. Kemmerer, N. Milickovic, K. Karouzakis, D. Baltas and N. Zamboglou, Optimized bounding boxes for three-dimensional treatment planning in brachytherapy, Med. Phys. 27 2333-2342, 2000
N. Milickovic, D. Baltas, S. Giannouli, M. Lahanas and N. Zamboglou, CT imaging based digitally reconstructed radiographs and their application in brachytherapy, Phys. Med. Biol. 45 1-14, 2000
K. Karouzakis, M. Lahanas, N. Milickovic, D. Baltas and N. Zamboglou, Brachytherapy dose–volume histogram computations using optimized stratified sampling methods, Med. Phys. 29 424-432, 2002
M. Lahanas, N. Milickovic, D. Baltas and N. Zamboglou, Application of Multiobjective Evolutionary Algorithms for Dose Optimization Problems in Brachytherapy, in Proceedings of the first international conference, EMO 2001, Zurich, Switzerland, edited by E. Zitzler, K. Deb, L. Thiele, C. A. Coello Coello, D. Corne, Lecture Notes in Computer Science Vol. 1993, Springer, 574-587, 2001
N. Milickovic, M. Lahanas, D. Baltas and N. Zamboglou, Comparison of Evolutionary and Deterministic Multiobjective Algorithms for Dose Optimization in Brachytherapy, in Proceedings of the first international conference, EMO 2001, Zurich, Switzerland, edited by E. Zitzler, K. Deb, L. Thiele, C. A. Coello Coello, D. Corne, Lecture Notes in Computer Science Vol. 1993, Springer 167-180, 2001
M. Lahanas, N. Milickovic, M. Papagiannopoulou, K. Karouzakis, D. Baltas and N. Zamboglou, Application of a Hybrid NSGA-II Multiobjective Algorithm for Anatomy based Dose Optimization in Brachytherapy, EUROGEN 2001 - Evolutionary Methods for Design, Optimisation and Control with Applications to Industrial Problems, Athens, Greece 19-21 September 2001
N. Milickovic, M. Lahanas, M. Papagiannopoulou, K. Karouzakis, D. Baltas and N. Zamboglou, Application of Multiobjective Genetic Algorithms in Anatomy based Dose Optimization in Brachytherapy and its Comparison with Deterministic Algorithms, EUROGEN 2001 - Evolutionary Methods for Design, Optimisation and Control with Applications to Industrial Problems, Athens, Greece 19-21 September 2001
D. Baltas, N. Milickovic, S. Giannouli, M. Lahanas, C. Kolotas and N. Zamboglou, New tools of brachytherapy based on three-dimensional imaging Front. Radiat. Ther. Oncol. 34 59-70 2000
Additional References by others
E. Firle, C. Wei, S. Wesarg, Registration of 3D U/S and CT Images of the Prostate In: Lemke, Heinz U. (Ed.) et al: Computer Assisted Radiology and Surgery 2002. Proceedings, Berlin, Heidelberg, New York: Springer Verlag, 2002, pp. 527-532
C. Wei, G. Sakas, Q. Peng, A Free Hand Navigation System for Brachytherapy: (in Chinese). In: Jisuanji-fuzhu-sheji-yu-tuxingxue-xuebao = Journal of Computer-Aided Design & Computer Graphics 14 (2002), 9
Jorge Gómez Zardaín, Automatic Registration of PET and CT resp. PET and MRT Volume Data, Darmstadt, 2002 Darmstadt, Techn. Univ., Dipl.-Arbeit, 2002
S. Zimeras, G. Karangelis, E. Firle and T. Lauer, Shape Reconstruction Using Computer-assisted Segmentation Tools. In: Kim, Myoung-Hee (Ed.) u.a.; Deutsches Krebsforschungszentrum (DKFZ): Advanced Medical Image Processing. Proceedings 2002. Germany, 2002
G. Sakas, Trends in Medical Imaging: From 2D to 3D. In: Computers & Graphics 26 (2002), 4, pp. 577-587
G. Anagnostopoulos, D. Baltas, P. Karaiskos, P. Sandilos, P. Papagiannis and L. Sakelliou, Thermoluminescent dosimetry of the selectSeed 125I interstitial brachytherapy seed Med Phys, 29:709- 716, 2002.
D. Baltas, P. Karaiskos, P. Papagiannis, L. Sakelliou, E. Loeffler and N. Zamboglou, Beta versus gamma dosimetry close to Ir-192 brachytherapy sources Med. Phys. 28, 1875-1882, 2001
P. Karaiskos, P. Papagiannis, L. Sakelliou, G. Anagnostopoulos and D. Baltas, Monte Carlo dosimetry of the selectSeed 125I interstitial brachytherapy seed Med. Phys. 28, 1753-1760, 2001
N. Milickovic, D. Baltas and N. Zamboglou, Automatic Reconstruction of Catheters in CT Based Brachytherapy Treatment Planning Proc. IEEE Nuc. Sci. Symp. And Med. Imag. Conf., IEEE NSS/MIC 2001, San Diego, California, USA, 4-10 November, 2001.
N
Milickovic, D Baltas and N. Zamboglou, Algorithms
for Calculation of DRRs for Different Accelerator Voltages and Tools
for Work with DRRs
Proceedings of the
23rd IEEE EMBS Int. Conference, 23rd Annual International Conference
of the IEEE - Engineering in Medicine and Biology Society,
Istanbul,
Turkey, 25-28 October, 2001.
Chen, Wei; Firle, Evelyn: Active Patient Immobilization in Brachytherapy In: Center of Advanced European Studies and Research (CAESAR): Third Caesarium on Computer Aided Medicine: Handouts. Bonn, 2001
Chen, Wei; Cai, Wenli; Firle, Evelyn; Wang, Min; Peng, Qunsheng: A Hardware Assisted LDI Building Algorithm with Application to Hybrid Volume Rendering. In: Peng, Qunsheng (Ed.) u.a.: CAD/Graphics 2001. Proceedings of the Seventh International Conference on Computer Aided Design and Computer Graphics. Beijing, China : International Academic Publishers, 2001, S. 225 - 232
E. Firle and W. Chen, Semi-Automatic Registration for MR and CT Datasets. In: Center of Advanced European Studies and Research (CAESAR): Third Caesarium on Computer Aided Medicine : Handouts. Bonn, 2001
E. Firle, Semi-automatische Segmentierung der Prostata mit Hilfe von 3D Ultraschallaufnahmen. In: Handels, H. (Hrsg.) u.a.; Gesellschaft für Informatik (GI): Bildverarbeitung für die Medizin 2001. Proceedings : Algorithmen, Systeme, Anwendungen. Heidelberg : Springer, 2001, S. 262-266
Bruno Sauvonnet, Segmentierung von Plastikkathetern in 3D Ultraschallbildern. Darmstadt, 2001 Darmstadt, Techn. Univ., Dipl.-Arbeit, 2001
G. Karangelis, S. Zimeras, E. Firle, M.Wang, and G. Sakas, Volume Definition Tools for Medical Imaging Applications. In: Niessen, Wiro J. (ed.).: Medical Image Computing and Computer-Assisted Intervention - MICCAI 2001 Proceedings. : 4th International Conference. Berlin, Heidelberg, New York: Springer Verlag, 2001, pp. 1295-1297 (Lecture Notes in Computer Science 2208)
G.
Sakas, G. Karangelis, and A. Pommert, Advanced
Applications of Volume Visualization Methods in Medicine. In:
Stergiopoulos, Stergios (ed,): Advanced Signal Processing Handbook:
Theory and Implementation for Radar, Sonar, and Medical Imaging
Real-Time Systems.
Boca Raton
:
CRC Press LLC, 2001, pp. 7-1 - 7-71
S.
Walter,G. Straßmann, N. Zamboglou, C. Kolotas, and G. Sakas,
In
ViVo-Brachy: A Navigation System for Interstitial Brachytherapy. In:
Lemke, Heinz U.
(Ed.):
Computer Assisted Radiology and Surgery (CARS) 2000. Proceedings.
Amsterdam; Lausanne: Elsevier, 2000, S. 701-706
(International
Congress Series 1214)
G. Straßmann, C. Kolotas, R. Heyd, S. Walter, D. Baltas, T. Martin, H. Vogt, G. Ioannidis, G. Sakas,and N. Zamboglou, Navigation System for Interstitial Brachytherapy. In: Radiotherapy and Oncology 56 (2000), 1, 49-57
G. Sakas, S. Walter, M. Grimm, M. Richtscheid, Freihandakquisition, Rekonstruktion und Visualisierung von 3D- und 4D-Ultraschall. In: Der Radiologe 40 (2000), 295-303
G.
Sakas, Dreidimensionale
Bildrekonstruktion aus Ultraschall-Daten. In:
Spektrum der Wissenschaft. Digest: Wissenschaftliches
Rechnen.
Heidelberg
:
Spektrum der Wissenschaft, 1999, 88-93
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